Puneet Varma (Editor)

ACV synthetase

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EC number
  
6.3.2.26

IntEnz
  
IntEnz view

ExPASy
  
NiceZyme view

CAS number
  
57219-73-5

BRENDA
  
BRENDA entry

KEGG
  
KEGG entry

ACV synthetase (ACVS, -δ-(α-aminoadipoyl)--cysteinyl--valine synthetase, N-(5-amino-5-carboxypentanoyl)--cysteinyl--valine synthase, EC 6.3.2.26) is an enzyme that catalyzes the chemical reaction

3 ATP + L-2-aminohexanedioate + L-cysteine + L-valine + H2O 3 AMP + 3 PPi + N-[L-5-amino-5-carboxypentanoyl]-L-cysteinyl-D-valine

The five substrates of this enzyme are ATP, L-2-aminohexanedioate, L-cysteine, L-valine, and H2O, whereas its three products are AMP, diphosphate, and N-[L-5-amino-5-carboxypentanoyl]-L-cysteinyl-D-valine.

ACVS is an example of a nonribosomal peptide synthetase (NRPS). It participates in penicillin and cephalosporin biosyntheses.

References

ACV synthetase Wikipedia