Neha Patil


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Species  Human
Entrez  2181
Human  Mouse
Ensembl  ENSG00000123983
Aliases  ACSL3, ACS3, FACL3, PRO2194, acyl-CoA synthetase long-chain family member 3
External IDs  MGI: 1921455 HomoloGene: 3278 GeneCards: ACSL3

Long-chain-fatty-acid—CoA ligase 3 is an enzyme that in humans is encoded by the ACSL3 gene.


The protein encoded by this gene is an isozyme of the long-chain fatty-acid-coenzyme A ligase family. Although differing in substrate specificity, subcellular localization, and tissue distribution, all isozymes of this family convert free long-chain fatty acids into fatty acyl-CoA esters, and thereby play a key role in lipid biosynthesis and fatty acid degradation. This isozyme is highly expressed in brain, and preferentially utilizes myristate, arachidonate, and eicosapentaenoate as substrates. The amino acid sequence of this isozyme is 92% identical to that of rat homolog. Two transcript variants encoding the same protein have been found for this gene.


ACSL3 Wikipedia

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