Samiksha Jaiswal (Editor)

ACER1

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Species
  
Entrez
  
125981

Human
  
Ensembl
  
ENSG00000167769

Aliases
  
ACER1, ALKCDase1, ASAH3, alkaline ceramidase 1

External IDs
  
MGI: 2181962 HomoloGene: 15853 GeneCards: ACER1

Alkaline ceramidase 1 also known as ACER1 is a ceramidase enzyme which in humans is encoded by the ACER1 gene.

Contents

Function

ACER1 mediates cellular differentiation by controlling the generation of sphingosine (SPH) and sphingosine-1-phosphate (S1P).

Model organisms

Model organisms have been used in the study of ACER1 function. A conditional knockout mouse line called Acer1tm1a(EUCOMM)Wtsi was generated at the Wellcome Trust Sanger Institute. Male and female animals underwent a standardized phenotypic screen to determine the effects of deletion. Additional screens performed: - In-depth immunological phenotyping - in-depth bone and cartilage phenotyping

References

ACER1 Wikipedia


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