Species Human Entrez 125981 | Human Mouse Ensembl ENSG00000167769 | |
Aliases ACER1, ALKCDase1, ASAH3, alkaline ceramidase 1 External IDs MGI: 2181962 HomoloGene: 15853 GeneCards: ACER1 | ||
Alkaline ceramidase 1 also known as ACER1 is a ceramidase enzyme which in humans is encoded by the ACER1 gene.
Contents
Function
ACER1 mediates cellular differentiation by controlling the generation of sphingosine (SPH) and sphingosine-1-phosphate (S1P).
Model organisms
Model organisms have been used in the study of ACER1 function. A conditional knockout mouse line called Acer1tm1a(EUCOMM)Wtsi was generated at the Wellcome Trust Sanger Institute. Male and female animals underwent a standardized phenotypic screen to determine the effects of deletion. Additional screens performed: - In-depth immunological phenotyping - in-depth bone and cartilage phenotyping
References
ACER1 Wikipedia(Text) CC BY-SA