Girish Mahajan (Editor)

ACE inhibitor and thiazide combination

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Hydrochlorothiazide
  
Thiazide diuretic

ATC code
  
C09BA06 (WHO)

Trade names
  
Accuretic

Quinapril
  
Angiotensin converting enzyme inhibitor

AHFS/Drugs.com
  
Multum Consumer Information

Pregnancy category
  
US: D (Evidence of risk)

An ACE inhibitor and thiazide combination is a drug combination used to treat hypertension. They are given by oral administration.

Contents

Examples

  • Enalapril/hydrochlorothiazide (trade name Enalapril comp), wherein enalapril is the ACE inhibitor and hydrochlorothiazide is the thiazide.
  • Quinapril/hydrochlorothiazide (trade name Accuretic) is manufactured by Pfizer.
  • Lisinopril/hydrochlorothiazide is marketed as Prinzide by Merck & Co., Zestoretic by AstraZeneca, and many others.

    • Fosinopril/hydrochlorothiazide

    Fosinopril/hydrochlorothiazide (trade name Monopril HCT) has a boxed warning about its significant risk to cause fetal/neonatal morbidity and mortality when being used during pregnancy (2nd and 3rd trimesters).

    FDA modified its labeling on February, 2009 to include a precaution of drug interaction with gold. "Nitritoid reactions (symptoms include facial flushing, nausea, vomiting and hypotension) have been reported rarely in patients on therapy with injectable gold (sodium aurothiomalate) and concomitant ACE inhibitor therapy including Monopril/Monopril HCT."

    References

    ACE inhibitor and thiazide combination Wikipedia
    (Text) CC BY-SA