Rahul Sharma

ABM domain

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Symbol  ABM
Pfam clan  CL0032
SCOP  1n5t
Pfam  PF03992
InterPro  IPR007138
SUPERFAMILY  1n5t
ABM domain

In molecular biology, the ABM domain is a protein domain that is found in monooxygenases involved in the biosynthesis of several antibiotics by Streptomyces species, which can carry out oxygenation without the assistance of any of the prosthetic groups, metal ions or cofactors normally associated with activation of molecular oxygen. The structure of ActVA-Orf6 monooxygenase from Streptomyces coelicolor, which is involved in actinorhodin biosynthesis, reveals a dimeric alpha+beta barrel topology. There is also a conserved histidine that is likely to be an active site residue. In the S. coelicolor protein SCO1909 this domain occurs as a repeat.

References

ABM domain Wikipedia


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