Species Human Entrez 64240 | Human Mouse Ensembl ENSG00000138075 | |
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Aliases ABCG5, STSL, ATP binding cassette subfamily G member 5 External IDs MGI: 1351659 HomoloGene: 31909 GeneCards: ABCG5 | ||
ATP-binding cassette sub-family G member 5 is a protein that in humans is encoded by the ABCG5 gene.
Contents
Function
The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the White subfamily. The protein encoded by this gene functions as a half-transporter to limit intestinal absorption and promote biliary excretion of sterols. It is expressed in a tissue-specific manner in the liver, colon, and intestine. This gene is tandemly arrayed on chromosome 2, in a head-to-head orientation with family member ABCG8. Mutations in this gene may contribute to sterol accumulation and atheroschlerosis, and have been observed in patients with sitosterolemia.
Interactive pathway map
Click on genes, proteins and metabolites below to link to respective articles.