Rahul Sharma

AB 001

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CAS Number  1345973-49-0
ChemSpider  26286891
Formula  C24H31NO
PubChem CID  57404070
UNII  H657DIA015
Molar mass  349.508 g/mol
AB-001 httpsuploadwikimediaorgwikipediacommonsthu
Legal status  CA: Schedule II DE: Anlage II (Prohibited)

AB-001 or 1-pentyl-3-(1-adamantoyl)indole is a designer drug that was found as an ingredient in synthetic cannabis smoking blends in Ireland in 2010 and Hungary and Germany in 2011. It is unclear who AB-001 was originally developed by, but it is structurally related to compounds such as AM-1248 and its corresponding 1-(tetrahydropyran-4-ylmethyl) analogue, which are known to be potent cannabinoid agonists with moderate to high selectivity for CB2 over CB1. The first published synthesis and pharmacological evaluation of AB-001 revealed that it acts as a full agonist at CB1 (EC50 = 35 nM) and CB2 receptors (EC50 = 48 nM). However, AB-001 was found to possess only weak cannabimimetic effects in rats at doses up to 30 mg/kg, making it less potent than the carboxamide analogue APICA, which possesses potent cannabimimetic activity at doses of 3 mg/kg.

References

AB-001 Wikipedia


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