Puneet Varma

AM 1248

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CAS Number  335160-66-2
ChemSpider  8469262
Formula  C26H34N2O
PubChem CID  10293794
Molar mass  390.561 g/mol
AM-1248 httpsuploadwikimediaorgwikipediacommonsthu
Legal status  CA: Schedule II NZ: Temporary Class

AM-1248 is a drug that acts as a moderately potent agonist for both the cannabinoid receptors CB1 and CB2, but with some dispute between sources over its exact potency and selectivity. Replacing the 3-(1-naphthoyl) group found in many indole derived cannabinoid ligands, with an adamantoyl group, generally confers significant CB2 selectivity, but reasonable CB1 affinity and selectivity is retained when an N-methylpiperidin-2-ylmethyl substitution is used at the indole 1-position. The related compound 1-pentyl-3-(1-adamantoyl)indole was identified as having been sold as a cannabinoid designer drug in Hungary in 2011, along with another synthetic cannabinoid AM-679.


Sweden's public health agency suggested to classify AM-1248 as hazardous substance on June 1, 2015.

As of October 2015 AM-1248 is a controlled substance in China.


AM-1248 Wikipedia

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