Neha Patil (Editor)

8 Oxoguanine

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8-Oxoguanine httpsuploadwikimediaorgwikipediacommons33

Gene music using protein sequence of ogg1 8 oxoguanine dna glycosylase


8-Oxoguanine (8-hydroxyguanine, 8-oxo-Gua, or OH8Gua) is one of the most common DNA lesions resulting from reactive oxygen species and can result in a mismatched pairing with adenine resulting in G to T and C to A substitutions in the genome. In humans, it is primarily repaired by DNA glycosylase OGG1. It can be caused by ionizing radiation, in connection with oxidative metabolism.

Contents

8-Oxoguanine Figure 1

In body fluids

8-Oxoguanine 8Oxoguanine Wikipedia

Increased concentrations of 8-oxoguanine in body fluids have been found to be associated with increased risk of mutagenesis and carcinogenesis.

8-Oxoguanine File8oxoG forming Hoogsten base pair with dAsvg Wikimedia Commons

Care must be taken in the assay of 8-oxoguanine due to the ease with which it can be oxidised during extraction and the assay procedure.

8-Oxoguanine 78dihydro8oxoguanine C5H5N5O2 ChemSpider
8-Oxoguanine Kevin Ahern39s Biochemistry BB 451551 at Oregon State University

References

8-Oxoguanine Wikipedia


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