Kalpana Kalpana (Editor)

8 Carboxamidocyclazocine

Updated on
Share on FacebookTweet on TwitterShare on LinkedInShare on Reddit
Covid-19
CAS Number  911207-68-6
ChemSpider  30845204
3D model (Jmol)  Interactive image
PubChem CID  10086063
Formula  C19H26N2O
Molar mass  298.205 g/mol
8-Carboxamidocyclazocine httpsuploadwikimediaorgwikipediacommonsthu

8-Carboxamidocyclazocine (8-CAC) is an opioid analgesic drug related to cyclazocine, invented by medicinal chemist Mark P. Wentland and co-workers in Cogswell Laboratory at Rensselaer Polytechnic Institute. Similarly to cyclazocine, 8-CAC acts as an agonist at both the μ and κ opioid receptors, but has a much longer duration of action than cyclazocine, and does not have μ antagonist activity. Unexpectedly it was discovered that the phenolic hydroxyl group of cyclazocine could be replaced by a carboxamido group with only slight loss of potency at opioid receptors, and this discovery has subsequently been used to develop a large number of novel opioid derivatives where the phenolic hydroxy group has been replaced by either carboxamide or a variety of larger groups. Due to their strong κ-opioid agonist activity, these drugs are not suited for use as analgesics in humans, but have instead been researched as potential drugs for the treatment of cocaine addiction.

References

8-Carboxamidocyclazocine Wikipedia


Similar Topics
Andrés Silvera
Nikki Finke
Karel Hnik
Topics
 
B
i
Link
H2
L