7,8 didemethyl 8 hydroxy 5 deazariboflavin synthase

7,8-didemethyl-8-hydroxy-5-deazariboflavin synthase (EC 2.5.1.77, FO synthase) is an enzyme with systematic name 5-amino-6-(D-ribitylamino)uracil:4-hydroxyphenylpyruvate, 4-methylphenol transferase. This enzyme catalyses the following chemical reaction

5-amino-6-(D-ribitylamino)uracil + 3-(4-hydroxyphenyl)pyruvate + 2 S-adenosyl-L-methionine + H₂O ⇌ 7,8-didemethyl-8-hydroxy-5-deazariboflavin + 2 L-methionine + 2 5'-deoxyadenosine + oxalate + NH₃

This enzyme binds a 4Fe-4S cluster.