Harman Patil (Editor)

60S ribosomal protein L14

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Covid-19
Species  Human
Entrez  9045
Human  Mouse
Ensembl  ENSG00000188846
60S ribosomal protein L14
Aliases  RPL14, CAG-ISL-7, CTG-B33, L14, RL14, hRL14, ribosomal protein L14
External IDs  MGI: 1914365 HomoloGene: 68375 GeneCards: RPL14

60S ribosomal protein L14' is a protein that in humans is encoded by the RPL14 gene.

Contents

Function

Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L14E family of ribosomal proteins. It contains a basic region-leucine zipper (bZIP)-like domain. The protein is located in the cytoplasm. This gene contains a trinucleotide (GCT) repeat tract whose length is highly polymorphic; these triplet repeats result in a stretch of alanine residues in the encoded protein. Transcript variants utilizing alternative polyA signals and alternative 5'-terminal exons exist but all encode the same protein. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome.

Interactions

RPL14 has been shown to interact with PHLDA1.

References

60S ribosomal protein L14 Wikipedia


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