EC number 4.2.3.12 IntEnz IntEnz view ExPASy NiceZyme view | CAS number 97089-82-2 BRENDA BRENDA entry KEGG KEGG entry | |
In enzymology, a 6-pyruvoyltetrahydropterin synthase (PTPS) (EC 4.2.3.12) is an enzyme that catalyzes the following chemical reaction:
Contents
7,8-Dihydroneopterin triphosphate
Hence, this enzyme has one substrate, 7,8-Dihydroneopterin triphosphate, and two products, 6-pyruvoyltetrahydropterin and triphosphate.
Enzyme Class
This enzyme belongs to the family of lyases, to be specific, those carbon-oxygen lyases acting on phosphates. The systematic name of this enzyme class is 6-[(1S,2R)-1,2-dihydroxy-3-triphosphooxypropyl]-7,8-dihydropterin triphosphate-lyase (6-pyruvoyl-5,6,7,8-tetrahydropterin-forming).
Synonyms
Other names in common use include 2-amino-4-oxo-6-[(1S,2R)-1,2-dihydroxy-3-triphosphooxypropyl]-7,8-, and dihydroxypteridine triphosphate lyase. This enzyme participates in tetrahydrobiopterin biosynthesis.
Genetics
This enzyme 6-pyruvoyltetrahydropterin synthaseis encoded by the PTS gene.
Clinical significance
6-pyruvoyl-tetrahydropterin synthase deficiency belongs to the rare recessive disorder
Structural studies
As of mid-2010, 13 structures have been solved for this class of enzymes, with PDB accession codes 3M0N, 3LZE, 3LX3, 3I2B, 2DTT, 1GTQ, 1B66, 1B6Z, 1Y13, 2A0S, 2DJ6, 2G64, and 2OBA.