Routes ofadministration Oral PubChem CID 10511982 ChEMBL CHEMBL6376 | ATC code none ChemSpider 8687383 Molar mass 193.24 g/mol | |
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Legal status Uncontrolled (but may be covered under the Federal Analogue Act in the United States and under similar bills in other countries) | ||
6-Methyl-3,4-methylenedioxyamphetamine (6-Methyl-MDA) is an entactogen and psychedelic drug of the amphetamine class. It was first synthesized in the late 1990s by a team including David E. Nichols at Purdue University while investigating derivatives of MDA and MDMA.
6-Methyl-MDA has IC50 values of 783nM, 28,300nM, and 4,602nM for inhibiting the reuptake of serotonin, dopamine, and norepinephrine in rat synaptosomes. In animal studies it substitutes for MBDB, MMAI, LSD, and DOI, though not amphetamine, but only partially and at high doses. Thus, while several-fold less potent than its analogues 2-methyl-MDA and 5-methyl-MDA, and approximately half as potent as MDA, 6-methyl-MDA is still significantly active, and appropriate doses may be similar to or somewhat higher than those of MDMA.