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6' Guanidinonaltrindole

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6'-Guanidinonaltrindole httpsuploadwikimediaorgwikipediacommonscc

6'-Guanidinonaltrindole (6'-GNTI) is a κ−δ-opioid receptor selective ligand used in scientific research.

With 6'-GNTI, evidence was provided for the first time that receptor oligomizeration plays functional role in living organisms.

6'-GNTI is an extremely biased agonist of the κ-opioid receptor. It is a potent partial agonist of the G protein pathway but does not recruit the β-arrestin pathway. Due to its functional selectivity for the G protein pathway, 6'-GNTI functions as an antagonist of nonbiased KOR agonists on the β-arrestin pathway. It is thought that 6'-GTNI may be able to produce analgesia without dysphoria and with a lower incidence of tolerance.

References

6'-Guanidinonaltrindole Wikipedia


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