Rahul Sharma (Editor)

5 Methoxytryptamine

Updated on
Share on FacebookTweet on TwitterShare on LinkedInShare on Reddit
Covid-19
CAS Number  608-07-1
IUPHAR/BPS  107
KEGG  C05659
Molar mass  190.242 g/mol
PubChem CID  1833
ChemSpider  1767
ChEBI  CHEBI:2089
5-Methoxytryptamine

n acetyl 5 methoxytryptamine 10


5-Methoxytryptamine (5-MT), also known as mexamine, is a tryptamine derivative closely related to the neurotransmitters serotonin and melatonin. 5-MT has been shown to occur naturally in the body in low levels. It is biosynthesized via the deacetylation of melatonin in the pineal gland.

Contents

5-MT acts as a full agonist at the 5-HT1, 5-HT2, 5-HT4, 5-HT6, and 5-HT7 receptors. It has no affinity for the 5-HT3 receptor and it should also be noted that its affinity for the 5-HT1E receptor is very weak in comparison to the other 5-HT1 receptors. Its affinity for the 5-HT5A receptor is unknown.

Measured affinity for some receptors (not a complete list):

  • 5-HT1B receptors (Ki = 35 nM)
  • 5-HT1D receptors (Ki = 7.3 nM)
  • 5-HT1E receptors (Ki = 3151 nM)
  • 5-HT1F receptors (Ki = 1166 nM)
  • 5-HT2A receptors (Ki = 295 nM)
  • 5-HT2B receptors (Ki = 16.4 nM)
  • 5-HT2C receptors (Ki = 52.48 nM)
  • 5-HT4 receptors (Ki = 501.18 nM)
  • 5-HT6 receptors (Ki = 69.18 nM)
  • 5-HT7 receptors (Ki = 5.01 nM)
  • Medical vocabulary what does 5 methoxytryptamine mean


    References

    5-Methoxytryptamine Wikipedia


    Similar Topics
    A Perfect 36
    Pat Boutette
    Adam Sherburne
    Topics
     
    B
    i
    Link
    H2
    L