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4 Hydroxycyclophosphamide

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Covid-19
CAS Number  40277-05-2
ChemSpider  90110
Formula  C7H15Cl2N2O3P
PubChem CID  99735
ChEMBL  CHEMBL731
Molar mass  277.08 gĀ·mol
4-Hydroxycyclophosphamide

4-Hydroxycyclophosphamide is in the class of oxazaphosphorine compounds, and is the main, active metabolite of cyclophosphamide and of mafosfamide after they partially metabolized by cytochrome P450. It is then partially tautomerized into aldophosphamide, which, in turn, easily enters live cells and then is partially detoxified into inactive carboxycyclophosphamide by the enzyme ALDH, but partially is hydrolyzed by another cell's enzyme phosphatase to the two directly cytotoxic metabolites - phosphoramide mustard and acrolein.

References

4-Hydroxycyclophosphamide Wikipedia


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