The series begins in New Orleans with a man named George covered in blood running towards a police officer who subdues and begins to arrest him when George ignores his commands to stop.
2 days earlier, George is going to see Judith for one last job. George is a recovering addict and he is hoping to use the money from the job to leave New Orleans and start a new life with his girlfriend Jenny. He goes to meet Eddie behind a bar, collect a CD and deliver it to Pat. Yet, when he arrives, Eddie has been attacked and the disc destroyed. Eddie, barely alive, uses his bloody finger to scrawl some letters and numbers on George's forearm before he dies.
In the background, a vampire runs past George, who flees into the bar Eddie had come from. However, indoors he runs into his old dealer who wants payment for the drugs. George is then water tortured in the bathroom until the vampire kills the dealer. Not wanting to stay long, George runs to Pat's apartment with the code. Pat sends the code to Cynthia in Los Angeles. Feeling that his job is done George heads back to his place. As Pat is about to hack into a website, he witnesses Cynthia on a webcam being beheaded by another vampire.
George returns to his apartment to find Jenny upset and in withdrawal. George feels he has been followed and hides with Jenny in the closet. A vampire has followed George to his apartment and now is looking for him. George uses a nailbat to attack and escape the vampire. Confused, they both run to see Pat, only to find him bleeding to death. He asks George to deliver a message to Judith and begs George to kill him. When he hesitates, Pat becomes a vampire, only to have Jenny behead him with a katana. Wanting answers, they head for Judith who tells them to take the message to Chad.
They arrive at Chad's with the message. Written in a hidden code, Chad needs time to crack it. While waiting outside, George and Jenny talk about what they will do after Cynthia pays him. Suddenly, Jenny is pulled backward into a below-ground alley by a vampire. George follows and finds her bleeding and transforming into a vampire. She attacks him, and he is forced to kill Jenny with a length of pipe. He goes back into the building only to find a bloody stump of Chad's arm, clutching a piece of paper on which the decoded message is written.
After reading the message, George runs into the street. We come back to when George is being arrested and discovers the message reveals the vampires' plan – a "feeding" in Barrow, Alaska, which will take place the following night.
George's story continues in 30 Days of Night: Dust to Dust.Trip Hope as Eddie
Tiffany Barrett as Vampire 3
Perry Cornelius as Police Officer
Marilyn Johnson as Judith
Brittney Kara as Kate
Andrew Laurichas as George
Dani Owen as Jenny
Patrick Logan Pace as Vampire 1
Jeremy Shranko as Luis
Shawn G. Smitha as Cal
Geoff Stirling as Chad
T.J. Zale as Pat
Each clip was released on FEARnet.com and FEARnet On Demand between September 13 until October 18, a day before the movie premiered in theaters. The miniseries is available on FEAR.net, for those living within the United States, and on YouTube. On October 19 all 7 episodes were combined into a 30-minute film available On Demand.
The series was released on Region 2 DVD in the United Kingdom on 14 April 2008 to coincide with the release of the movie on DVD and Blu-Ray.