Synonyms 3-FPM, 3-FPH, PAL-593 ChemSpider 37509994HCl: 34212559 | PubChem CID 54673723HCl: 75481405 UNII BEV6RF569G | |
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Legal status UK: Under Psychoactive Substances ActIllegal in Sweden and Switzerland CAS Number 1350768-28-3HCl: 1803562-83-5 | ||
3-Fluorophenmetrazine (also known as 3-FPM, 3-FPH and PAL-593) is a phenylmorpholine-based stimulant and fluorinated analogue of phenmetrazine that has been sold online as a designer drug.
Contents
Pharmacology
3-FPM acts as a norepinephrine-dopamine releasing agent with EC50 values of 43 nM and 30 nM, respectively. It shows only negligible efficacy as a releaser of serotonin, with an EC50 value of 2558 nM.
Evaluation of its metabolic pathway revealed N‐oxidation, aryl hydroxylation and subsequent O‐methylation, alkyl hydroxylation, oxidation, and degradation of the ethyl‐bridge yielding the O/N‐bis‐dealkylated metabolite, combinations thereof and further glucuronidation or sulfations.
Legality
Sweden's public health agency suggested to classify 3-Fluorophenmetrazine as illegal narcotic on June 1, 2015. It was finally classified on October 15, 2015.
3-Fluorophenmetrazine is illegal in Switzerland as of December 2015.