Density 1.233 g/cm³ | Appearance Off-white powder | |
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3-Aminobenzamide is a benzamide. It is an off-white powder and has the chemical formula C7H8N2O.
Contents
Preparation
3-Aminobenzamide can be prepared though the reduction of 3-nitrobenzamide by catalytic hydrogenation.
Uses
3-Aminobenzamide is an inhibitor of poly ADP ribose polymerase (PARP), an enzyme responsible for DNA repair, transcription control, and programmed cell death.<ref="Purnell1980"/> When PARP is activated it rapidly uses up stores of nicotinamide adenine dinucleotide (NAD+) in the cell as it performs DNA repair. Low levels of NAD+ deplete the amount of ATP found in the cell which can lead to cell death. The structure of 3-aminobenzamide is similar to that of NAD+ so it binds to PARP and prevents it from using up NAD+. PARP is often a target of cancer therapy and so 3-aminobenzamide could potentially be used as an anticancer drug.