3β Dihydroprogesterone

3β-Dihydroprogesterone (3β-DHP), also known as 3β-hydroxyprogesterone or pregn-4-en-3β-ol-20-one (4-pregnenolone), is an endogenous steroid. It is biosynthesized by 3β-hydroxysteroid dehydrogenase from progesterone. Unlike 3α-dihydroprogesterone, 3β-DHP does not act as a positive allosteric modulator of the GABA_A, which is in accordance with the fact that other 3β-hydroxylated progesterone metabolites such as isopregnanolone and epipregnanolone similarly do not act as potentiators of this receptor and instead inhibit it as well as reverse the effects of potentiators like allopregnanolone.