2C D

2C-D (2,5-dimethoxy-4-methylphenethylamine, also known as 2C-M) is a psychedelic drug of the 2C family that is sometimes used as an entheogen. It was first synthesized in 1970 by a team from the Texas Research Institute of Mental Sciences, and its activity was subsequently investigated in humans by Alexander Shulgin. The full name of the chemical is 2,5-dimethoxy-4-methylphenethylamine. In his book PiHKAL (Phenethylamines i Have Known And Loved), Shulgin lists the dosage range as being from 20 to 60 mg and many people recommend higher doses. Lower doses (generally 10 mg or less) of 2C-D have been explored as a potential nootropic, albeit with mixed results. 2C-D is generally taken orally, though may be insufflated (i.e. taken nasally). Insufflating tends to cause intense pain, however, and the dosage level is usually much lower, typically in the region of 1 to 15 mg.

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Not much information is known about the toxicity of 2C-D, as no major studies have been conducted. According to Shulgin, the effects of 2C-D typically last for 4–6 hours. Shulgin himself referred to this substance as a “pharmacological tofu,” meaning that when mixed with other substances, it can extend or potentiate their effects without coloring the experience too much, in a manner similar to how tofu absorbs the flavors of sauces or spices it is cooked with. Some people have claimed 2C-D is relatively uninteresting on its own, but many other users have strongly disagreed with this assessment and believe instead 2C-D to be a true psychedelic in its own right. Hanscarl Leuner, working in Germany, explored the use of 2C-D under the name LE-25 in psychotherapeutic research.