23S rRNA (adenosine1067 2' O) methyltransferase

23S rRNA (adenosine¹⁰⁶⁷-2'-O)-methyltransferase (EC 2.1.1.230, 23S rRNA A1067 2'-methyltransferase, thiostrepton-resistance methylase, nosiheptide-resistance methyltransferase) is an enzyme with systematic name S-adenosyl-L-methionine:23S rRNA (adenosine¹⁰⁶⁷-2'-O)-methyltransferase. This enzyme catalyses the following chemical reaction

S-adenosyl-L-methionine + adenosine¹⁰⁶⁷ in 23S rRNA ⇌ S-adenosyl-L-homocysteine + 2'-O-methyladenosine¹⁰⁶⁷ in 23S rRNA

The methylase that is responsible for autoimmunity in the thiostrepton producer Streptomyces azureus.