23S rRNA (adenine2503 C8) methyltransferase

23S rRNA (adenine²⁵⁰³-C⁸)-methyltransferase (EC 2.1.1.224, Cfr (gene)) is an enzyme with systematic name S-adenosyl-L-methionine:23S rRNA (adenine²⁵⁰³-C⁸)-methyltransferase. This enzyme catalyses the following chemical reaction

2 S-adenosyl-L-methionine + adenine²⁵⁰³ in 23S rRNA ⇌ S-adenosyl-L-homocysteine + L-methionine + 5'-deoxyadenosine + 8-methyladenine²⁵⁰³ in 23S rRNA

This enzyme is a member of the 'AdoMet radical' (radical SAM) family.