| 4–6 (4–4 MEAC)|
| Terry Sims (2nd year)|
| Mid-Eastern Athletic Conference|
The 2016 Bethune–Cookman Wildcats football team represented Bethune–Cookman University in the 2016 NCAA Division I FCS football season. They were led by second-year head coach Terry Sims and played their home games at Municipal Stadium. They were a member of the Mid-Eastern Athletic Conference (MEAC). They finished the season 4–6, 4–4 in MEAC play to finish in a two way tie for fifth place.
^[a] The game between Alcorn State and Bethune–Cookman was canceled due to inclement weather. The game was delayed due to lightning in the second quarter with 7:13 remaining. Alcorn was leading 13–7. Both schools' athletic directors decided not to reschedule the game, thus declaring it a "no contest".
^[b] The game between North Carolina A&T and Bethune–Cookman was rescheduled from October 13, 2016 due to damages sustained to Daytona Beach from Hurricane Matthew.
^[c] The game between South Carolina State and Bethune–Cookman was postponed in advance of the arrival of Hurricane Matthew. The game was rescheduled for November 26 on October 7, 2016.
Game was cancelled due to inclement weather and was declared a "no contest".
2016 Bethune–Cookman Wildcats football team Wikipedia