The 2015–16 San Antonio Spurs season was the 49th season of the franchise, 40th in the National Basketball Association (NBA) and 43rd in the San Antonio area. On April 10, the Spurs' home winning streak came to an end with a loss to the defending NBA Champions Golden State Warriors.
Kawhi Leonard was selected to play in the 2016 NBA All-Star Game as a starter. This marked the first All-Star appearance for Leonard.
With the acquisitions of David West and LaMarcus Aldridge, the Spurs finished with a 67–15 record, their best winning percentage in franchise history, earning them the Southwest Division title. The Spurs also set a franchise record for most wins in a season with 67 and tied the NBA record for most home wins in a season with 40 (tying the 1985–86 Boston Celtics 40–1 home record).
In the first round of the 2016 NBA Playoffs, the Spurs faced the injury depleted Memphis Grizzlies, and swept them in four games. However, in the Conference Semifinals, the team was defeated 2–4 by the Oklahoma City Thunder. They would become the first team to since the 2007 Dallas Mavericks to finish with 67 wins and be eliminated before the conference finals.
Following the season, longtime captain Tim Duncan retired.