| Andrey Golubev|
| Jürgen Melzer|
Nikolay Davydenko was the defender of championship title; however, he lost to Andrey Golubev in the third round.
Unseeded Golubev, the biggest surprise of this tournament, won in the final 6–3, 7–5, against Jürgen Melzer.
2010 International German Open – Singles Wikipedia
All seeds receive a bye into the second round.