Puneet Varma (Editor)

2 Methoxyethyl 18 methoxycoronaridinate

Updated on
Share on FacebookTweet on TwitterShare on LinkedInShare on Reddit
PubChem CID  10070278
Formula  C24H32N2O4
Molar mass  412.521 g/mol
ChemSpider  9212214
3D model (Jmol)  Interactive image
2-Methoxyethyl-18-methoxycoronaridinate httpsuploadwikimediaorgwikipediacommonsthu

(–)-2-Methoxyethyl-18-methoxycoronaridinate (ME-18-MC) is a second generation synthetic derivative of ibogaine developed by the research team led by the pharmacologist Stanley D. Glick from the Albany Medical College and the chemist Martin E. Kuehne from the University of Vermont. In animal studies it has shown similar efficacy to the related compound 18-methoxycoronaridine (18-MC) at reducing self-administration of morphine and methamphetamine but with higher potency by weight, showing anti-addictive effects at the equivalent of half the minimum effective dose of 18-MC. Similarly to 18-MC itself, ME-18-MC acts primarily as a selective α3β4 nicotinic acetylcholine antagonist, although it has a slightly stronger effect than 18-MC as an NMDA antagonist, and its effects on opioid receptors are weaker than those of 18-MC at all except the kappa opioid receptor, at which it has slightly higher affinity than 18-MC.


2-Methoxyethyl-18-methoxycoronaridinate Wikipedia