Puneet Varma (Editor)

2 Aminoisobutyric acid

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Covid-19
Formula  C4H9NO2
CAS ID  62-57-7
Molar mass  103.12 g/mol
Appearance  white crystalline powder
2-Aminoisobutyric acid

2-Aminoisobutyric acid, or α-aminoisobutyric acid (AIB) or α-methylalanine or 2-methylalanine, is an amino acid with the structural formula is H2N-C(CH3)2-COOH. It is contained in some antibiotics of fungal origin, e.g. alamethicin and some lantibiotics. It is not one of the proteinogenic amino acids and rather rare in nature (cf. Non-proteinogenic amino acids). α-Aminoisobutyric acid is a strong helix inducer in peptides. Oligomers of AIB form 310 helices.

In the laboratory, 2-aminoisobutyric acid may be prepared from acetone cyanohydrin, by reaction with ammonia followed by hydrolysis.

References

2-Aminoisobutyric acid Wikipedia


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