EC number 2.3.1.117 IntEnz IntEnz view ExPASy NiceZyme view | CAS number 88086-34-4 BRENDA BRENDA entry KEGG KEGG entry | |
In enzymology, a 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase (EC 2.3.1.117) is an enzyme that catalyzes the chemical reaction
succinyl-CoA + (S)-2,3,4,5-tetrahydropyridine-2,6-dicarboxylate + H2OThe 3 substrates of this enzyme are succinyl-CoA, (S)-2,3,4,5-tetrahydropyridine-2,6-dicarboxylate, and H2O, whereas its two products are CoA and N-succinyl-L-2-amino-6-oxoheptanedioate.
This enzyme belongs to the family of transferases, specifically those acyltransferases transferring groups other than aminoacyl groups. The systematic name of this enzyme class is succinyl-CoA:(S)-2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase. Other names in common use include tetrahydropicolinate succinylase, tetrahydrodipicolinate N-succinyltransferase, tetrahydrodipicolinate succinyltransferase, succinyl-CoA:tetrahydrodipicolinate N-succinyltransferase, succinyl-CoA:2,3,4,5-tetrahydropyridine-2,6-dicarboxylate, and N-succinyltransferase. This enzyme participates in lysine biosynthesis.
Structural studies
As of late 2007, 4 structures have been solved for this class of enzymes, with PDB accession codes 1KGQ, 1KGT, 2TDT, and 3TDT.