2',3' cyclic nucleotide 2' phosphodiesterase

In enzymology, a 2',3'-cyclic-nucleotide 2'-phosphodiesterase (EC 3.1.4.16) is an enzyme that catalyzes the chemical reaction

nucleoside 2',3'-cyclic phosphate + H₂O ⇌ nucleoside 3'-phosphate

Thus, the two substrates of this enzyme are nucleoside 2',3'-cyclic phosphate and H₂O, whereas its product is nucleoside 3'-phosphate.

This enzyme belongs to the family of hydrolases, specifically those acting on phosphoric diester bonds. The systematic name of this enzyme class is nucleoside-2',3'-cyclic-phosphate 3'-nucleotidohydrolase. Other names in common use include ribonucleoside 2',3'-cyclic phosphate diesterase, 2',3 '-cyclic AMP phosphodiesterase, 2',3'-cyclic nucleotidase, cyclic 2',3'-nucleotide 2'-phosphodiesterase, cyclic 2',3'-nucleotide phosphodiesterase, 2',3'-cyclic nucleoside monophosphate phosphodiesterase, 2',3'-cyclic AMP 2'-phosphohydrolase, cyclic phosphodiesterase:3'-nucleotidase, 2',3'-cyclic nucleotide phosphohydrolase, 2':3'-cyclic phosphodiesterase, and 2':3'-cyclic nucleotide phosphodiesterase:3'-nucleotidase. This enzyme participates in purine metabolism and pyrimidine metabolism.