The 1991 MTV Video Music Awards aired live on September 5, 1991, honoring the best music videos from June 2, 1990, to June 15, 1991. The show was hosted by Arsenio Hall at the Universal Amphitheatre in Los Angeles.
This year saw the introduction of a new category, Best Long Form Video; however, this category would not be handed out again until the 2016 ceremony where it was renamed Breakthrough Long Form Video. Meanwhile, the award for Best Post-Modern Video was renamed Best Alternative Video.
R.E.M. led the night both in awards and in nominations. Their video for "Losing My Religion" not only won Video of the Year, but it also took home a total of six awards, making them the biggest winners of the night. Furthermore, R.E.M.'s ten nominations also made them the most nominated artist that night and "Losing My Religion" the most nominated video of the night.