| Saprissa (3rd title)|| Cartaginés|
| 12 (from 3 associations)|
Costa Rican club Deportivo Saprissa obtained its 3rd regional title after winning the final round.
Saprissa advanced 3–1 on aggregate.
FAS advanced 2–0 on aggregate.
Barrio México 1–1 Municipal on aggregate. Barrio México won 3–1 on penalty shoot-outs
Cartaginés 1–1 Juventud Olímpica on aggregate. Cartaginés won 5–4 on penalty shoot-outs
Tiquisate advanced 2–1 on aggregate.
Comunicaciones advanced 3–0 on aggregate.
1978 Copa Fraternidad Wikipedia
Apparently Saprissa, Cartaginés and Comunicaciones eliminated FAS, Barrio México and Tiquisate in a semifinal round.