The 1946 VFL Grand Final was an Australian rules football game contested between the Essendon Football Club and Melbourne Football Club, held at the Melbourne Cricket Ground on 5 October 1946. It was the 48th annual Grand Final of the Victorian Football League, staged to determine the premiers for the 1946 VFL season. The match, attended by 73,743 spectators, was won by Essendon by a margin of 63 points, marking that club's 8th premiership flag and 6th involving a grand final.
Essendon won comfortably despite trailing at half time. A tally of 11 goals and 8 behinds in the third quarter by Essendon took the game away from Melbourne. This remains the best third quarter score by any team in a VFL/AFL Grand Final.
Wally Lock, Melbourne's half back, was playing his 100th VFL game.
This was the first of six successive Grand Final appearances by Essendon.