The 1921 Centre vs. Harvard football game, played October 29, 1921, was a college football game between Centre College and Harvard University. Centre beat Harvard 6–0, in what is widely considered one of the greatest upsets in college football history.
The teams first met in 1920, at Harvard Stadium in the Boston neighborhood of Allston, with Harvard coming off a Rose Bowl victory and an undefeated national championship season in 1919 (the school's fourth national championship in the prior ten years). Coming into the Centre game, Harvard was also undefeated and unscored upon in the 1920 season. Meanwhile, Centre College, a tiny school of 300 students in Kentucky, had little history of success in football before their current coach, Charley Moran, and star quarterback, Bo McMillin, arrived on campus in 1917.
The Centre Praying Colonels shocked Harvard in the 1920 game simply by taking a 14–7 halftime lead. But, in the second half, Centre withered before the superior Harvard squad, and Harvard won the game 31–14. Following the game, Harvard's captain offered the game ball to Centre's quarterback Bo McMillin, but McMillin declined the ball and promised "We'll be back next year to take it home with us."
After a scoreless half and early in the third quarter, Red Roberts told McMillin "it's time to score, ride my hump" and McMillin ran for a 32-yard touchdown. He dodged three of Harvard's secondary.
Bob Fisher said after the game "In Bo McMillin Centre has a man who is probably the hardest in the country to stop."
All around Danville students painted the "impossible formula" of C6H0.
The Centre victory was a shock, but perhaps not a fluke; the team would finish the 1921 season 10–1, defeating several of the nation's powerhouses including VPI, Auburn, Arizona, and Clemson. Their only defeat was a 22–14 loss to powerful Texas A&M in The Dixie Classic (forerunner of the Cotton Bowl), Dallas, Texas, on January 2, 1922 (this is the game where A&M's famous 12th man was born). (Bo McMillin got married in Dallas the day before the game, and the Colonels were in the midst of a grueling long distance trip from home by train, having played Arizona in San Diego, California the week prior). Up until their final game of the season the Colonels outscored their opponents by a margin of 314 to 6.
In 1950, the Associated Press named C6H0 the greatest sports upset of the first half of the 20th century. In 2005, The New York Times called it "arguably the upset of the century in college football." In 2006, ESPN named it the third-biggest upset in the 138-year history of college football.
On the 75th anniversary of C6H0, Centre challenged Harvard to a rematch. Harvard declined.