|Covid-19|April 25 – Martin Waldseemüller publishes his Cosmographiae Introductio ("Introduction to Universal Cosmography") and accompanying wall map, the first to show the Americas as a separate continent, naming them in honour of Amerigo Vespucci, his friend and idol.
July 4 – Martin Luther is ordained a priest of the Catholic Church.
August 20 – Guru Nanak Dev becomes the first guru and leader of the Sikh religion.
The Timurid dynasty ends when Uzbeks under Muhammad Shaybani capture the capital, Herat, and the Emir Badi' al-Zaman Mirza flees.
The Portuguese occupy Mozambique and the islands of Socotra and Lamu.
Cardinal Cisneros is appointed major inquisitor of Castile.
King Henry VII of England prosecutes lords for keeping private armies, which might threaten his régime.
King James IV grants a patent for the first printing press in Scotland to Walter Chapman and Andrew Myllar.
Raphael paints The Deposition, among other works.
The Aztec New Fire ceremony is held for the last time (according to Bernardino de Sahagún).
January 1 – Anna of Brandenburg, Duchess of Mecklenburg-Güstrow (d. 1567)
Catherine of Austria, Queen of Portugal (d. 1578)
Luca Longhi, Italian painter (d. 1580)
January 18 – Ferdinando Sanseverino, Prince of Salerno (d. 1572)
January 25 – Johannes Oporinus, Swiss printer (d. 1568)
February 11 – Philip II, Metropolitan of Moscow, Russian Orthodox monk (d. 1569)
February 21 – James, Duke of Rothesay, Scottish prince (d. 1508)
March 7 – Magdalena of Saxony (d. 1534)
March 25 – Thomas White, English politician (d. 1566)
March 29 – Henry II, Duke of Münsterberg-Oels and Count of Glatz (d. 1548)
April 13 – Konrad Hubert, German theologian and hymnwriter (d. 1577)
June 5 – Ferdinand of Portugal, Duke of Guarda and Trancoso, Portuguese nobleman (d. 1534)
June 6 – Annibale Caro, Italian poet and Knight of Malta (d. 1566)
June 25 – Marie of Baden-Sponheim, Margravine of Baden by birth and by marriage Duchess of Bavaria (d. 1580)
July 25 – Chamaraja Wodeyar IV, King of Mysore (d. 1576)
August 2 – William Waldegrave, English Member of Parliament (d. 1554)
August 15 – George III, Prince of Anhalt-Dessau, German prince (d. 1553)
September 16 – Jiajing Emperor of China (d. 1567)
September 27 – Guillaume Rondelet, French physician (d. 1566)
Johannes Sturm, German educator (d. 1589)
Giacomo Barozzi da Vignola, Italian architect (d. 1573)
October 4 – Francis Bigod, British noble (d. 1537)
October 19 – Viglius, name taken by Wigle Aytta van Zwichem, Dutch politician (d. 1577)
October 26 – Alvise I Mocenigo, Doge (d. 1577)
October 29 – Fernando Alvarez de Toledo, Spanish general (d. 1582)
November 25 – Joos de Damhouder, Belgian jurist (d. 1581)
December 18 – Ōuchi Yoshitaka, Japanese warlord (d. 1551)
Bálint Bakfark, Hungarian composer (d. 1576)
Sir Ralph Sadler, English statesman (d. 1587)
Jacques Arcadelt, Franco-Flemish composer (d. 1568)
Inés Suárez, Spanish conquistadora (d. 1580)
Anne Boleyn, Second Queen of Henry VIII of England (born this year or 1501; d. 1536)
January 17 – Henry IV of Neuhaus (b. 1442)
March 12 – Cesare Borgia, Italian general and statesman. (b. 1475)
March 21 – Jan Feliks "Szram" Tarnowski, Polish nobleman (b. 1471)
April 2 – Francis of Paola, Italian founder of the Order of the Minims (b. 1416)
July 29 – Martin Behaim, German navigator and geographer (b. 1459)
August 15 – John V, Duke of Saxe-Lauenburg (b. 1439)
August 23 – Jean Molinet, French writer (b. 1435)
August 24 – Cecily of York, English princess (b. 1469)
December – Ingeborg Tott, influential Swedish noblewoman, wife of Swedish regent Sten Sture the elder
Year 1507 (MDVII) was a common year starting on Friday (link will display the full calendar) of the Julian calendar.