The 116th Ohio Infantry was organized Marietta and Gallipolis, Ohio, and mustered in September 18, 1862, for three years service under the command of Colonel James Washburn. Companies F and K mustered in October 28, 1862, and joined regiment at Buckhannon, Virginia.
The regiment was attached to Railroad Division, West Virginia, to January 1863. Romney, West Virginia, Defenses of the Upper Potomac, VIII Corps, Middle Department, to March 1863. 1st Brigade, 2nd Division, VIII Corps, Middle Department, to June 1863. 1st Brigade, Elliott's Command, VIII Corps, to July 1863. 1st Brigade, 1st Division, Department of the Susquehanna, July 1863. McReynolds' Command, Martinsburg, West Virginia, Department of West Virginia, to December 1863. 1st Brigade, 1st Division, West Virginia, to April 1864. 1st Brigade. 1st Infantry Division, West Virginia, to December 1864. 1st Brigade, Independent Division, XXIV Corps, Army of the James, to June 1865.
The 116th Ohio Infantry mustered out of service June 14, 1865, at Richmond, Virginia. Companies F and K were consolidated with the 62nd Ohio Infantry.
Left Ohio for Parkersburg, Va., October 16; then moved to Clarksburg and Buckhannon. Moved to New Creek November 9, and to Moorefield December 12. Duty at Moorefield, Va., December 15, 1862, to January 10, 1863. Moorefield January 3. At Romney until March 17. Near Romney February 16. At Winchester, Va., until June. Operations in Shenandoah Valley April 20–29. Scout toward Wardensville and Strasburg April 20. Scout to Strasburg April 25–29. Bunker Hill June 13 (Companies A and I). Battle of Winchester June 13–15. Retreat to Harper's Ferry, W. Va., June 15–16; then to Washington, D.C., July 1–4, and joined Army of the Potomac at Frederick, Md., July 5. Pursuit of Lee to Manassas Gap, Va., July 5–24. Wapping Heights, Va., July 23. At Martinsburg, W. Va., August 4, 1863, to April 29, 1864. Skirmish at Hedgesville October 16, 1863 (detachment). Sigel's Expedition from Martinsburg to New Market April 29-May 16, 1864. Battle of New Market May 15. Advance on Staunton May 24-June 6. Piedmont June 5. Occupation of Staunton June 6. Hunter's raid on Lynchburg June 10-July 1. Lynchburg June 17–18. Ordered to the Shenandoah Valley July. Battle of Kernstown-Winchester, July 24. Sheridan's Shenandoah Valley Campaign August 7-November 28. Charlestown August 21, 22, and 29. Berryville September 3, Battle of Winchester, Opaquan Creek September 19. Fisher's Hill September 22. Cedar Creek October 13, Battle of Cedar Creek October 19. Duty at Opequan Crossing November 18 to December 19. Moved to Washington, D.C., December 19; then to Aiken's Landing, Va. Siege of Petersburg and Richmond December 27, 1864, to April 2, 1865. Appomattox Campaign March 28-April 9, Hatcher's Run March 29-April 1. Fall of Petersburg April 2. Pursuit of Lee April 3–9. Rice's Station April 6. Appomattox Court House April 9. Surrender of Lee and his army. Duty at Richmond, Va., until June.
The regiment lost a total of 185 men during service; 4 officers and 90 enlisted men killed or mortally wounded, 3 officers and 88 enlisted men died of disease.Colonel James Washburn
Lieutenant Colonel Thomas F. Wildes - commanded at the battle of Opequon
Corporal Freeman C. Thompson, Company F - Medal of Honor recipient for action at Petersburg, Virginia, April 2, 1865
Private Joseph Van Matre, Company G - Medal of Honor recipient for action at Petersburg, Virginia, April 2, 1865