Supriya Ghosh (Editor)

10 Formyltetrahydrofolate

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Covid-19
Formula  C20H23N7O7
Molar mass  473.4393 g/mol
10-Formyltetrahydrofolate CAS No2800342LGlutamic acidN42amino345678

10-Formyltetrahydrofolate (10-CHO-THF) is a form of tetrahydrofolate that acts as a donor of formyl groups in anabolism. In these reactions 10-CHO-THF is used as a substrate in formyltransferase reactions. This is important in purine biosynthesis, where 10-CHO-THF is a substrate for phosphoribosylaminoimidazolecarboxamide formyltransferase, as well as in the formylation of the methionyl initiator tRNA (fMet-tRNA), when 10-CHO-THF is a substrate for methionyl-tRNA formyltransferase.

10-Formyltetrahydrofolate The Folate and methionine cycles Abreviations 10fTHF Figure

Biosynthesis

10-CHO-THF is produced either by the enzyme methenyltetrahydrofolate cyclohydrolase via the reaction

10-Formyltetrahydrofolate The structure of 10formyl folate a and 10formyl tet Openi5,10-methenyltetrahydrofolate + H2O 10-formyltetrahydrofolate

or by the enzyme formate-tetrahydrofolate ligase via the reaction

10-Formyltetrahydrofolate httpsuploadwikimediaorgwikipediacommonsthuATP + formate + tetrahydrofolate ADP + phosphate + 10-formyltetrahydrofolate

It can be converted back into tetrahydrofolate (THF) by formyltetrahydrofolate dehydrogenase or THF and formate by formyltetrahydrofolate deformylase.

10-Formyltetrahydrofolate 10Formyltetrahydrofolate Dehydrogenase Requires a 4
10-Formyltetrahydrofolate EthanolInduced Upregulation of 10Formyltetrahydrofolate
10-Formyltetrahydrofolate OneCarbon Metabolic Pathway Rewiring in Escherichia coli Reveals an
10-Formyltetrahydrofolate Patent WO2009019478A1 Treatments and prevention of hydrocephalus
10-Formyltetrahydrofolate KEGG COMPOUND C00234

References

10-Formyltetrahydrofolate Wikipedia


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