Neha Patil (Editor)

1 pyrroline 4 hydroxy 2 carboxylate deaminase

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EC number
IntEnz  IntEnz view
ExPASy  NiceZyme view
CAS number  9054-77-7
KEGG  KEGG entry

In enzymology, a 1-pyrroline-4-hydroxy-2-carboxylate deaminase (EC is an enzyme that catalyzes the chemical reaction

1-pyrroline-4-hydroxy-2-carboxylate + H2O 2,5-dioxopentanoate + NH3

Thus, the two substrates of this enzyme are 1-pyrroline-4-hydroxy-2-carboxylate and H2O, whereas its two products are 2,5-dioxopentanoate and NH3.

This enzyme belongs to the family of hydrolases, those acting on carbon-nitrogen bonds other than peptide bonds, specifically in cyclic amidines. The systematic name of this enzyme class is 1-pyrroline-4-hydroxy-2-carboxylate aminohydrolase (decyclizing). This enzyme is also called HPC deaminase. This enzyme participates in arginine and proline metabolism.


1-pyrroline-4-hydroxy-2-carboxylate deaminase Wikipedia