Puneet Varma (Editor)

1 alkyl 2 acetylglycerophosphocholine esterase

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EC number
IntEnz  IntEnz view
ExPASy  NiceZyme view
CAS number  76901-00-3
KEGG  KEGG entry

In enzymology, a 1-alkyl-2-acetylglycerophosphocholine esterase (EC is an enzyme that catalyzes the chemical reaction

1-alkyl-2-acetyl-sn-glycero-3-phosphocholine + H2O 1-alkyl-sn-glycero-3-phosphocholine + acetate

Thus, the two substrates of this enzyme are 1-alkyl-2-acetyl-sn-glycero-3-phosphocholine and H2O, whereas its two products are 1-alkyl-sn-glycero-3-phosphocholine and acetate.

This enzyme belongs to the family of hydrolases, specifically those acting on carboxylic ester bonds. The systematic name of this enzyme class is 1-alkyl-2-acetyl-sn-glycero-3-phosphocholine acetohydrolase. Other names in common use include 1-alkyl-2-acetyl-sn-glycero-3-phosphocholine acetylhydrolase, and alkylacetyl-GPC:acetylhydrolase. This enzyme participates in ether lipid metabolism.

Structural studies

As of late 2007, 7 structures have been solved for this class of enzymes, with PDB accession codes 1BWP, 1BWQ, 1BWR, 1ES9, 1FXW, 1VYH, and 1WAB.


1-alkyl-2-acetylglycerophosphocholine esterase Wikipedia