1-Tetralone is an organic chemical compound with the molecular formula C10H10O. It is a common intermediate in organic synthesis. It is a ketone derivative of tetralin, a hydrogenated derivative of naphthalene. A related compound is 2-tetralone.
1-Tetralone can be prepared by several methods. A typical methods involve intramolecular cyclisation of phenylbutyric acid.
The Haworth reaction is a classic method for the synthesis of tetralone. Benzene is reacted with succinic anhydride by a Friedel–Crafts acylation, the intermediate product is reduced and a second Friedel–Crafts acylation takes place upon the addition of acid.
1-Tetralone is a precursor to 1-naphthol by dehydrogenation:
O → C10
OH + H2