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1 Hydroxypyrene

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1-Hydroxypyrene

1-Hydroxypyrene is a human metabolite. It can be found in urine of outdoor workers exposed to air pollution.

Contents

Experiments in pig show that urinary 1-hydroxypyrene is a metabolite of pyrene, when given orally.

Relationship with smoking

Highly significant differences and dose-response relationships with regard to cigarettes smoked per day were found for 2-, 3- and 4-hydroxyphenanthrene and 1-hydroxypyrene, but not for 1-hydroxyphenanthrene.

Pyrene degradation product by microorganisms

Pyrene alone or a mixture of pyrene with three-ringed polycyclic aromatic hydrocarbons can be degraded by a Mycobacterium sp. strain isolated from mangrove sediments, forming amongst other products 1-hydroxypyrene.

References

1-Hydroxypyrene Wikipedia


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