1-Hydroxypyrene is a human metabolite. It can be found in urine of outdoor workers exposed to air pollution.
Experiments in pig show that urinary 1-hydroxypyrene is a metabolite of pyrene, when given orally.
Highly significant differences and dose-response relationships with regard to cigarettes smoked per day were found for 2-, 3- and 4-hydroxyphenanthrene and 1-hydroxypyrene, but not for 1-hydroxyphenanthrene.
Pyrene alone or a mixture of pyrene with three-ringed polycyclic aromatic hydrocarbons can be degraded by a Mycobacterium sp. strain isolated from mangrove sediments, forming amongst other products 1-hydroxypyrene.