Supriya Ghosh (Editor)

1,9 Pyrazoloanthrone

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Density  1.46 g/cm³
Appearance  yellow
Boiling point  489.3 °C
1,9-Pyrazoloanthrone httpsuploadwikimediaorgwikipediacommonsthu

1,9-Pyrazoloanthrone is a chemical compound that is a derivative of anthrone. It is used in biochemical studies as an inhbitor of c-Jun N-terminal kinases (JNKs).

Derivatives of 1,9-pyrazoloanthrone have a variety of biological activities. For example, 5-(aminoalkyl)amino derivatives have been investigated as anticancer agents.

Synthesis

1,9-Pyrazoloanthrone can be synthesized by the condensation of 2-chloroanthraquinone with anhydrous hydrazine in pyridine at 100 °C. Purification is achieved via conversion to the N-acetyl derivative which is crystallized from acetic acid, followed by hydrolysis of the acetyl group with ammonium hydroxide in methanol.

References

1,9-Pyrazoloanthrone Wikipedia


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