Suvarna Garge (Editor)

1,2 Dimethoxybenzene

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Density  1.08 g/cm³
Formula  C8H10O2
Molar mass  138.16 g/mol
1,2-Dimethoxybenzene wwwsigmaaldrichcomcontentdamsigmaaldrichstr

1,2-Dimethoxybenzene, commonly known as veratrole, is an organic compound with the formula C6H4(OCH3)2. It is a colorless liquid, with a pleasant odor and slight solubility in water. It is the dimethyl ether derived from pyrocatechol.



1,2-Dimethoxybenzene is naturally occurring. Its biosynthesis entails the methylation of guaiacol by guaiacol O-methyltransferase. 1,2-Dimethoxybenzene is an insect attractant. Guaiacol O-methyltransferase gene is first scent gene discovered so far in any plant species.


1,2-Dimethoxybenzene is a building block for the organic synthesis of other aromatic compounds. Veratrole is relatively electron-rich and thus readily undergoes electrophilic substitution.

An example of the use of veratrole is in the synthesis of Domipizone.

Veratrole can easily be brominated with NBS to give 4-bromoveratrole.

  • 1,3-Dimethoxybenzene
  • 1,4-Dimethoxybenzene
  • References

    1,2-Dimethoxybenzene Wikipedia