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(pyruvate dehydrogenase (acetyl transferring)) phosphatase

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EC number
  
3.1.3.43

IntEnz
  
IntEnz view

ExPASy
  
NiceZyme view

CAS number
  
9073-70-5

BRENDA
  
BRENDA entry

KEGG
  
KEGG entry

In enzymology, a [pyruvate dehydrogenase (acetyl-transferring)]-phosphatase (EC 3.1.3.43) is an enzyme that catalyzes the chemical reaction

[pyruvate dehydrogenase (acetyl-transferring)] phosphate + H2O [pyruvate dehydrogenase (acetyl-transferring)] + phosphate

Thus, the two substrates of this enzyme are pyruvate dehydrogenase (acetyl-transferring) phosphate and H2O, whereas its two products are pyruvate dehydrogenase (acetyl-transferring) and phosphate.

This enzyme belongs to the family of hydrolases, specifically those acting on phosphoric monoester bonds. The systematic name of this enzyme class is [pyruvate dehydrogenase (acetyl-transferring)]-phosphate phosphohydrolase. Other names in common use include pyruvate dehydrogenase phosphatase, phosphopyruvate dehydrogenase phosphatase, [pyruvate dehydrogenase (lipoamide)]-phosphatase, and [pyruvate dehydrogenase (lipoamide)]-phosphate phosphohydrolase.

Structural studies

As of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code 2PNQ.

References

(pyruvate dehydrogenase (acetyl-transferring))-phosphatase Wikipedia