EC number 3.1.3.43 ExPASy NiceZyme view | CAS number 9073-70-5 | |
In enzymology, a [pyruvate dehydrogenase (acetyl-transferring)]-phosphatase (EC 3.1.3.43) is an enzyme that catalyzes the chemical reaction
Thus, the two substrates of this enzyme are pyruvate dehydrogenase (acetyl-transferring) phosphate and H2O, whereas its two products are pyruvate dehydrogenase (acetyl-transferring) and phosphate.
This enzyme belongs to the family of hydrolases, specifically those acting on phosphoric monoester bonds. The systematic name of this enzyme class is [pyruvate dehydrogenase (acetyl-transferring)]-phosphate phosphohydrolase. Other names in common use include pyruvate dehydrogenase phosphatase, phosphopyruvate dehydrogenase phosphatase, [pyruvate dehydrogenase (lipoamide)]-phosphatase, and [pyruvate dehydrogenase (lipoamide)]-phosphate phosphohydrolase.
Structural studies
As of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code 2PNQ.