In enzymology, a [acyl-carrier-protein] phosphodiesterase (EC 18.104.22.168) is an enzyme that catalyzes the chemical reactionholo-[acyl-carrier-protein] + H2O
Thus, the two substrates of this enzyme are [[holo-[acyl-carrier-protein]]] and H2O, whereas its two products are 4'-phosphopantetheine and [[apo-[acyl-carrier-protein]]].
This enzyme belongs to the family of hydrolases, specifically those acting on phosphoric diester bonds. The systematic name of this enzyme class is holo-[acyl-carrier-protein] 4'-pantetheine-phosphohydrolase. Other names in common use include ACP hydrolyase, ACP phosphodiesterase, AcpH, and [acyl-carrier-protein] 4'-pantetheine-phosphohydrolase. This enzyme participates in pantothenate and coa biosynthesis.
As of late 2007, two structures have been solved for this class of enzymes, with PDB accession codes 1T5B and 1TIK.