Harman Patil (Editor)

(acyl carrier protein) phosphodiesterase

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EC number
IntEnz  IntEnz view
ExPASy  NiceZyme view
CAS number  37288-21-4
KEGG  KEGG entry

In enzymology, a [acyl-carrier-protein] phosphodiesterase (EC is an enzyme that catalyzes the chemical reaction

holo-[acyl-carrier-protein] + H2O 4'-phosphopantetheine + apo-[acyl-carrier-protein]

Thus, the two substrates of this enzyme are [[holo-[acyl-carrier-protein]]] and H2O, whereas its two products are 4'-phosphopantetheine and [[apo-[acyl-carrier-protein]]].

This enzyme belongs to the family of hydrolases, specifically those acting on phosphoric diester bonds. The systematic name of this enzyme class is holo-[acyl-carrier-protein] 4'-pantetheine-phosphohydrolase. Other names in common use include ACP hydrolyase, ACP phosphodiesterase, AcpH, and [acyl-carrier-protein] 4'-pantetheine-phosphohydrolase. This enzyme participates in pantothenate and coa biosynthesis.

Structural studies

As of late 2007, two structures have been solved for this class of enzymes, with PDB accession codes 1T5B and 1TIK.


(acyl-carrier-protein) phosphodiesterase Wikipedia