Girish Mahajan (Editor)

(S) tetrahydroprotoberberine N methyltransferase

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EC number  2.1.1.122
IntEnz  IntEnz view
ExPASy  NiceZyme view
CAS number  106878-42-6
BRENDA  BRENDA entry
KEGG  KEGG entry

In enzymology, a (S)-tetrahydroprotoberberine N-methyltransferase (EC 2.1.1.122) is an enzyme that catalyzes the chemical reaction

S-adenosyl-L-methionine + (S)-7,8,13,14-tetrahydroprotoberberine S-adenosyl-L-homocysteine + cis-N-methyl-(S)-7,8,13,14-tetrahydroprotoberberine

Thus, the two substrates of this enzyme are S-adenosyl methionine and (S)-7,8,13,14-tetrahydroprotoberberine, whereas its two products are S-adenosylhomocysteine and cis-N-methyl-(S)-7,8,13,14-tetrahydroprotoberberine.

This enzyme belongs to the family of transferases, specifically those transferring one-carbon group methyltransferases. The systematic name of this enzyme class is S-adenosyl-L-methionine:(S)-7,8,13,14-tetrahydroprotoberberine cis-N-methyltransferase. This enzyme is also called tetrahydroprotoberberine cis-N-methyltransferase. This enzyme participates in alkaloid biosynthesis i.

References

(S)-tetrahydroprotoberberine N-methyltransferase Wikipedia