Samiksha Jaiswal (Editor)

(R,R) Tetrahydrochrysene

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Covid-19
CAS Number  138090-06-9
ChemSpider  394097
Molar mass  320.42476 g/mol
PubChem CID  446849
Formula  C22H24O2
3D model (Jmol)  Interactive image
(R,R)-Tetrahydrochrysene

(R,R)-Tetrahydrochrysene ((R,R)-THC) is a drug used to study the estrogen receptors (ERs) in scientific research. It is an ERβ antagonist and an ERα agonist with 10-fold higher affinity for ERβ relative to ERα. (R,R)-THC is a silent antagonist of ERβ, and, uniquely relative to other known ERβ antagonists, a passive antagonist of the receptor.

(S,S)-Tetrahydrochrysene ((S,S)-THC) also binds to the ERs, but in contrast to (R,R)-THC, (S,S)-THC is an agonist of both ERα and ERβ and has 20-fold lower affinity for ERβ relative to (R,R)-THC.

References

(R,R)-Tetrahydrochrysene Wikipedia


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