Rahul Sharma (Editor)

(R) 6 hydroxynicotine oxidase

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EC number
IntEnz  IntEnz view
ExPASy  NiceZyme view
CAS number  37233-46-8
KEGG  KEGG entry

In enzymology, a (R)-6-hydroxynicotine oxidase (EC is an enzyme that catalyzes the chemical reaction

(R)-6-hydroxynicotine + H2O + O2 1-(6-hydroxypyridin-3-yl)-4-(methylamino)butan-1-one + H2O2

The 3 substrates of this enzyme are (R)-6-hydroxynicotine, H2O, and O2, whereas its two products are 1-(6-hydroxypyridin-3-yl)-4-(methylamino)butan-1-one and H2O2.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-NH group of donors with oxygen as acceptor. The systematic name of this enzyme class is (R)-6-hydroxynicotine:oxygen oxidoreductase. Other names in common use include D-6-hydroxynicotine oxidase, and 6-hydroxy-D-nicotine oxidase. It employs one cofactor, FAD.

Structural studies

As of late 2007, 3 structures have been solved for this class of enzymes, with PDB accession codes 2BVF, 2BVG, and 2BVH.


(R)-6-hydroxynicotine oxidase Wikipedia