EC number 1.5.3.6 IntEnz IntEnz view ExPASy NiceZyme view | CAS number 37233-46-8 BRENDA BRENDA entry KEGG KEGG entry | |
In enzymology, a (R)-6-hydroxynicotine oxidase (EC 1.5.3.6) is an enzyme that catalyzes the chemical reaction
(R)-6-hydroxynicotine + H2O + O2The 3 substrates of this enzyme are (R)-6-hydroxynicotine, H2O, and O2, whereas its two products are 1-(6-hydroxypyridin-3-yl)-4-(methylamino)butan-1-one and H2O2.
This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-NH group of donors with oxygen as acceptor. The systematic name of this enzyme class is (R)-6-hydroxynicotine:oxygen oxidoreductase. Other names in common use include D-6-hydroxynicotine oxidase, and 6-hydroxy-D-nicotine oxidase. It employs one cofactor, FAD.
Structural studies
As of late 2007, 3 structures have been solved for this class of enzymes, with PDB accession codes 2BVF, 2BVG, and 2BVH.
References
(R)-6-hydroxynicotine oxidase Wikipedia(Text) CC BY-SA