Species Human Entrez 79088 | Human Mouse Ensembl ENSG00000130818 | |
Aliases ZNF426, K-RBP, zinc finger protein 426 External IDs MGI: 1920248 HomoloGene: 23435 GeneCards: ZNF426 |
Zinc finger protein 426 is a protein that in humans is encoded by the ZNF426 gene.
Function
Kaposi's sarcoma-associated herpesvirus (KSHV) can be reactivated from latency by the viral protein RTA. The protein encoded by this gene is a zinc finger transcriptional repressor that interacts with RTA to modulate RTA-mediated reactivation of KSHV. While the encoded protein can repress KSHV reactivation, RTA can induce degradation of this protein through the ubiquitin-proteasome pathway to overcome the repression. Several transcript variants encoding different isoforms have been found for this gene.
References
Zinc finger protein 426 Wikipedia(Text) CC BY-SA